

Cluster by global sequence homology
Structure discovery & homology modelling
Detection & alignment similar folds
Normalize sequence positions by structure homology
Analyze interactions with reference molecules
Recluster by interaction cavity homology
Define minimal set of structures that cover diversity
Create hotspot profiles for target applications
SBMM: Simulation-Based Metagenome Mapping
INPUT
Sequence
Structure
Structure
Sequence
Simulation
Sequence
Structure
Simulation
OUTPUT