Hotspot profiles are at the core of candidum's simulation technology. They are the fingerprint of an enzyme's interactions with a specific molecule. They tell us which regions matter and where we should start tuning.
No two fingerprints are the same. By introducing mutations into an enzyme, we detect subtle changes to the profiles and determine positions most sensitive to the development parameter.
With standardized positions and feedback from laboratory experiments, we can decipher the function of an enzyme on the basis of its profile and craft the fingerprint into the blueprint of an optimized variant.